{"id":3929,"date":"2024-07-30T00:43:54","date_gmt":"2024-07-30T03:43:54","guid":{"rendered":"https:\/\/stemcelltherapyargentina.com\/plasma-poor-in-platelets-that-is-researched-as-rich-in-platelets-and-that-for-some-professional-in-argentina-not-properly-trained-claims-in-his-social-networks-that-prp-does-not-work\/"},"modified":"2026-03-30T17:14:51","modified_gmt":"2026-03-30T20:14:51","slug":"plasma-poor-in-platelets-that-is-researched-as-rich-in-platelets-and-that-for-some-professional-in-argentina-not-properly-trained-claims-in-his-social-networks-that-prp-does-not-work","status":"publish","type":"post","link":"https:\/\/stemcelltherapyargentina.com\/en\/plasma-poor-in-platelets-that-is-researched-as-rich-in-platelets-and-that-for-some-professional-in-argentina-not-properly-trained-claims-in-his-social-networks-that-prp-does-not-work\/","title":{"rendered":"Plasma &#8220;poor in platelets&#8221; that is researched as &#8220;rich in platelets&#8221;&#8230; and that for some professional in Argentina not properly trained, claims in his social networks that &#8220;PRP&#8221; does not work, and discloses it as a scientific study of great scientific relevance&#8230;"},"content":{"rendered":"\n<p>Written by Dr. Matias Fernandez Vina.<br\/>CEO Stem Cell Therapy Argentina. <br\/>Diploma and Expert in Regenerative Medicine and Advanced Therapies from the Universidad Abierta Interamericana de Rosario, Argentina.  <\/p>\n\n<p>I am part of a virtual social group of Regenerative Medicine and Advanced Therapies, where we discuss cases of Regenerative Medicine&#8230; and by chance, I receive a <strong>&#8220;Screenshot&#8221;<\/strong>, where a colleague, calls <strong>&#8220;CHANTAS&#8221;<\/strong> to those who use PRP as a non-surgical treatment of osteoarthritis for patients not prepared for major knee surgery.<br\/><br\/>This arises from a<strong> scientific study<\/strong> published in<strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35638203\/\" target=\"_blank\" rel=\"noopener\">Bone Joint <\/a><\/strong>on<strong>&#8220;PRP<\/strong>&#8221; compared to placebo group for early degenerative knee osteoarthritis. <em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35638203\/\" target=\"_blank\" rel=\"noopener\">Lewis E, Merghani K, Robertson I, Mulford J, Prentice B, Mathew R, Van Winden P, Ogden K. The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial. Bone Joint J. 2022 Jun;104-B(6):663-671. doi: 10.1302\/0301-620X.104B6.BJJ-2021-1109.R2. PMID: 35638203.<\/a><\/em><\/p>\n\n<p>This study of <strong>&#8220;False PRP&#8221;<\/strong> refers to the injection of platelets and saline solution in a knee as being the same&#8230;.  <\/p>\n\n<p>The study is from Australia. As you will see as we analyze this research, something is definitely going on&#8230; some doctor, a specialist in traumatology in Argentina, defends that <strong>PRP should still NOT be used<\/strong>, and that even those who apply it, are <strong>&#8220;CHANTAS&#8221;<\/strong>, and <strong>obviously not for free&#8230;(as if these doctors have always operated\/worked for free..)<\/strong><\/p>\n\n<p>Let&#8217;s review this scientific study that they seek to have as an excuse to defend a totally decadent and obsolete position, (although they may think they have a back, but they really need a good chair of regenerative medicine at the University and know better what we are talking about&#8230;).<\/p>\n\n<p>This new research studied <strong>102 patients with knee arthritis and was published in The Journal of Bone and Joint Surgery<\/strong>, a journal with a scientific impact of 5.  <\/p>\n\n<p><strong>They randomized<\/strong> patients with mild to moderate knee arthritis into three groups:<strong> saline alone, PRP alone and <\/strong>then <strong>PRP for the first injection, and saline for two more injections<\/strong>. This is the first place where the study gets a little strange&#8230;. Given that three weekly PRP injections are the least common type of treatment for this type of knee arthritis, this design makes little common sense&#8230;. For example, if you wanted to compare a single PRP injection to a placebo, it would be a comparison to a single saline injection. If you wanted to compare three PRP injections to a placebo, you would obviously compare it to three saline injections.      <strong>However, it is a mystery why PRP and saline would ever be combined in the same treatment group&#8230;..  <em>we already got off to a bad start with the research design.  <\/em><\/strong><\/p>\n\n<p>In the end, the authors found no difference between the groups&#8230;. This contradicts nearly <strong>two dozen randomized, randomized studies with<\/strong> <em><strong>positive<\/strong><\/em> published on the use of REAL PRP (x7 times baseline) to treat osteoarthritis of the knee&#8230;. However, since this study used the <strong>Arthrex ACP<\/strong> device characterized by Magalon et al, which produces a <strong>pitiful X1.3 <\/strong>platelet <strong>concentration <\/strong>relative to basal in patient blood, if not even twice the basal value&#8230;, this study never used a<strong>&#8220;REAL PLASMA PLATELET RICH&#8230;. PRP&#8221;.<\/strong> Rather it is a<strong>&#8220;PLATELET POOR PLASMA<\/strong>&#8220;.  <\/p>\n\n<p>Therefore, the original title of this article was:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><em>The effectiveness of leucocyte-poor <strong>platelet-rich<\/strong> plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial<\/em>&#8230;.<\/li>\n<\/ul>\n\n<p><\/p>\n\n<p>But it should have been:  <\/p>\n\n<ul class=\"wp-block-list\">\n<li><em>The effectiveness of leucocyte-poor <strong>platelet-POOR<\/strong> plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial<\/em>&#8230;.<\/li>\n<\/ul>\n\n<p><br\/>The fact that leukocyte-poor and <strong>PLATELET-poor<\/strong> plasma works no better than saline injections for knee arthritis <strong>is NOT SURPRISING.<\/strong> We already know this, those who encourage in favor of surgery, discrediting colleagues in the field of regenerative medicine who also believe in surgical and non-surgical therapies (we are not against surgery), need to know that <strong><em>WE ALREADY KNOW that low dose PRP DOES NOT WORK in patients over 35 years of age.<\/em><\/strong><\/p>\n\n<p>I describe this as an example of a situation of having a <strong>major headache<\/strong>, and being medicated with a <strong>50mg\/day<\/strong> ibuprofen, when the <strong>correct<\/strong>dose should be<strong> 600mg\/day <\/strong> for this problem. <strong>Medicine does not work this way&#8230;<\/strong><\/p>\n\n<p>The vast majority of physicians who read these studies only read the abstract. Which means they <strong>will<\/strong> assume that both studies used <strong>legitimate PRP rather than just plasma<\/strong>. That has the potential to set the field back.  <\/p>\n\n<p>Simply put, if you are in the field of Regenerative Medicine, spread the word that these are<strong> NOT<\/strong><strong>&#8220;REAL PRP<\/strong>&#8221; studies. They are studies of <strong>FAKE PRP, disguised as PRP. <\/strong>They have platelet concentrations up to <strong>X2 times the basal value<\/strong>, and to be a <strong>REAL PRP, they must have X5.5 to X10, X15 or X20 inclusive.<\/strong> <\/p>\n\n<p>Finally, talk to your academic colleagues and inform them regarding the <strong>CORRECT PRP <\/strong>studies <strong>, such as those published in Nature [<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-83025-2\" target=\"_blank\" rel=\"noopener\">BANSAL<\/a>] or AJSM [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38410168\/\" target=\"_blank\" rel=\"noopener\">PATEL<\/a>] <\/strong>and the ones that are <strong>INCORRECT,<\/strong> such as this one or like the <strong><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2786501\" target=\"_blank\" rel=\"noopener\">RESTORE TRIAL, IN JAMA<\/a><\/strong>These doctors deserve to be singled out because they misinform patients and the population about a health problem that is controllable for many patients <strong>.<\/strong><\/p>\n\n<p><strong>The result? <\/strong> <strong>Bogus &#8220;PRP<\/strong>&#8221; <strong>studies<\/strong> continue to be produced. These are expensive and resource-intensive studies conducted by academics who don&#8217;t know what the endgame is. We should all denounce that.  <\/p>\n\n<p>As a summary of this blog, we invite Physicians who want to be properly trained in Regenerative Medicine <strong><a href=\"http:\/\/www.cursostemcell.com\" target=\"_blank\" rel=\"noopener\">in Regenerative Medicine<\/a><\/strong>to take a short training <strong>[even free and introductory]<\/strong>, or medium or long term, to get well informed before publishing comments or statements in their social networks that are <strong>FALSE, and DISLOYAL TO COLLEAGUES AND PATIENTS<\/strong>, mainly because the scientific evidence of PRP, is quite <strong>significant<\/strong> and above all, that is <strong>scientifically supported<\/strong>, not only by <strong>prestigious national societies, but by international consensus<\/strong>, mainly by groups such as the <a href=\"https:\/\/cdn.ymaws.com\/www.esska.org\/resource\/resmgr\/docs\/consensus_projects\/2203_orbit_brochure_spread.pdf%5D\" target=\"_blank\" rel=\"noopener\">ESSKA<\/a>, from Europe, through the <a href=\"https:\/\/cdn.ymaws.com\/www.esska.org\/resource\/resmgr\/docs\/consensus_projects\/2203_orbit_brochure_spread.pdf%5D\" target=\"_blank\" rel=\"noopener\">ORBIT<\/a> consensus.  <\/p>\n\n<p><em>In these cases, a phrase that I can define to close this blog is:<strong>&#8220;make sure that your words are soft and sweet, in case you have to swallow them one day..<\/strong>. you have to be careful with science, which often turns around, in an instant and suddenly&#8230; <\/em><\/p>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Written by Dr. Matias Fernandez Vina.CEO Stem Cell Therapy Argentina. Diploma and Expert in Regenerative Medicine and Advanced Therapies from the Universidad Abierta Interamericana de Rosario, Argentina. I am part of a virtual social group of Regenerative Medicine and Advanced Therapies, where we discuss cases of Regenerative Medicine&#8230; and by chance, I receive a &#8220;Screenshot&#8221;, [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":3921,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3929","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"_links":{"self":[{"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/posts\/3929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/comments?post=3929"}],"version-history":[{"count":1,"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/posts\/3929\/revisions"}],"predecessor-version":[{"id":3931,"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/posts\/3929\/revisions\/3931"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/media\/3921"}],"wp:attachment":[{"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/media?parent=3929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/categories?post=3929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stemcelltherapyargentina.com\/en\/wp-json\/wp\/v2\/tags?post=3929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}