Written by Dr. Matias Fernandez Vina.
CEO of Stem Cell Therapy in Argentina.
Diplomat and Expert in Regenerative Medicine and Advanced Therapies of the Open University Interamericana de Rosario, Argentina.
I am part of a group of virtual social Regenerative Medicine and Advanced Therapies, where we discuss cases of Regenerative Medicine.. and by chance, I get a "Screenshot", where a colleague, called "CHANTAS" This 'False PRP' study suggested that injecting platelets was equivalent to injecting saline into a knee...
This arises from a scientific study published in Bone Joint on the "PRP"compared with the placebo group for the degenerative osteoarthritis early knee. Lewis E, Merghani K, Robertson I, Mulford J, Prentice B, Mathew R, Van Winds P, Ogden K. The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial. Bone Joint J. 2022 Jun;104-B(6):663-671. doi: 10.1302/0301-620X.104B6.BJJ-2021-1109.R2. PMID: 35638203.
This study "False PRP" referred to be the same as the injection of platelets that of saline in a knee....
The study is of Australia. As you will see as we analyze this research, definitely something is happening.. any doctor, specialist in traumatology of Argentina, argues that the PRP is NOT yet to use it, and that even those who apply, are "CHANTAS", and obviously not for free...(as if these doctors always had operated/worked for free..)
We will review this scientific study that seek to take it as an excuse to defend a position is totally decadent and obsolete, (despite the fact that you may believe to have back, but I really need a good chair of regenerative medicine at the University and to know better what we are talking about..)
This new research studied 102 patients with knee arthritis and has been published in The Journal of Bone and Joint Surgery, a magazine with scientific impact of 5.
Randomized patients with knee arthritis, mild to moderate in three groups: saline solution alone, PRP alone and then PRP for the first injection and saline solution for two more injections. This is the first place where the study gets a little strange... Since three weekly injections of PRP are the type of treatment is less common for this type of arthritis of the knee, this design has little common sense... For example, if you wanted to compare a single injection of PRP with placebo, would be a comparison with a single injection of saline solution. If you would like to compare three injections of PRP with placebo, obviously he does it compare with three injections of saline solution. However, it is a mystery why you ever would combine PRP and saline solution in the same treatment group.... already started off wrong with the design of the research.
In the end, the authors found no differences between the groups... This contradicts almost two dozen randomized studies and randomized positive published on the use of PRP (x7 times a valorr basal) to treat osteoarthritis of the knee... however, given that this study used the device Arthrex ACP characterized by Magalon et al, which produces a unfortunate concentration of X1,3 platelets with respect to the baseline in the patient's blood, if not even double the baseline value.., this study never used a "REAL-PLATELET-RICH PLASMA.. PRP". But that is a "Platelet-POOR-Plasma«.
Therefore, the original title of this article was:
- The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial..
But it should have been:
- TI've effectiveness of leucocyte-poor platelet-POOR plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial..
The fact that the plasma poor in leukocytes and PLATELET-POOR does not work better than saline injections for knee arthritis IT IS NOT SURPRISING. We already know this, those who encourage them in favor of the surgery, discrediting colleagues in the field of regenerative medicine that also believe in the therapies, surgical and non-surgical (we are not against surgery), they have to know that We ALREADY KNOW that the low dose of PRP does NOT WORK in patients older than 35 years.
I describe this as an example of a situation of having a pain of head, and medicating with ibuprofen 50mg/day, when the dose correctshould be 600mg/day for this problem. The Medicine does not work this way.
The vast majority of physicians who read these studies only read the summary. Which means that assume both studies used PRP legitimate instead of only plasma. This has the potential to reverse the field.
Simply if you are in the field of Regenerative Medicine, then spread the word that these NO are studies "ACTUAL PRP". Studies are FALSE PRP, camouflaged as PRP. Have concentrations of platelet-up X2 times the baseline valueand to be a REAL-PRP, must have an X5.5 to X10, X15 or X20 inclusive.
Finally, talk with your academic colleagues and infórmalos respect to the studies CORRECT PRP, as published in Nature [BANSAL] or AJSM [PATEL] and those who are INCORRECT, like this or like the THE RESTORE TRIAL, IN JAMArepresenting some doctors in the background, have conflicts of interest are quite high, and heavy with the industry...These doctors deserve to be mentioned because they report bad to patients and the public about a health problem that can be controlled for many patients.
The result? Continue to occur bogus studies of "PRP". These studies are costly and require a lot of resources, made by academics who do not know what is at the end. We must all denounce that.
As a summary of this blog, we invite you to the Doctors who want to train correctly in Regenerative Medicineto take a training short [including free and introductory], or medium, or long-term, to become well informed before you leave to post comments, or statements on their social networks that are FALSE, and UNFAIR TO COLLEAGUES AND PATIENTSmainly because the scientific evidence of the PRP, it is quite significant and above all, that is proven scientificallynot only by national societies of prestige, but by the consensus internationall, mainly by groups such as the ESSKAfrom Europe, through the consensus ORBIT.
In these cases, a phrase that I can define to close this blog is: "keep your words soft and sweet, for if one day you have to tragártelas... you must be careful with the science, which many times gives back, in a single instant, and suddenly..
