Osteoarthritis (OA) is a degenerative disease of the articular cartilage whose main clinical manifestation is the joint pain. The database of the China Health and Retirement Longitudinal Study showed that the morbidity of symptomatic osteoarthritis (a score of Kellgren and Lawrence of knee ≥2, with knee pain) was 8.1% in China. With the development of aging in China, the incidence of OA is increasing. As there are no blood vessels, nerves or lymph in the articular cartilage, its self-healing ability is poor.
There are many types of non-surgical treatments, such as medications include nonsteroidal anti-inflammatory drugs, glucocorticoid, or opioids, [1,2] as well as physiotherapy treatments include the injection of hyaluronic acid (HA) or platelet-rich plasma (PRP) [3,4] to prevent pain and improve joint function. All of these methods can help prevent the pain temporarily but may not interrupt the degeneration of the articular cartilage.
After fat is removed from the human body through liposuction, microfragmented adipose tissue (MAT) can be obtained using an isolation and washing device without digestive enzymes. [5] it Is compatible with three-dimensional scaffolds, growth factors, and cell colonies such as mesenchymal stem cells (MSC). MAT injections can reduce pain in patients with osteoarthritis, improve joint function, and do not cause adverse events.
As innovative technology, the injection of MAT has been certified by the Food and Drug Administration (FDA) in the united States, the Brand Conformite Europeenne (CE) in Europe and the Administration of Therapeutic Products in Australia.
It is simple and secure, and can achieve high effectiveness with a single shot, even above 80% improvement.
At present a large number of basic studies and clinical trials focused on injections of MAT in patients with injury of the articular cartilage. According to the results of monitoring (including data not published), the injection of MAT can reduce pain in patients, improve joint function and does not cause adverse events. [27]
Even in patients who have undergone many failed treatments, such as surgery-arthroscopic meniscus, the reduction of pain through the injection of MAT is evident. [24]
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